Exceptional efficiency and uncompromising quality to Advance your Protein Production

Advanced Protein Production:

U.S.-Based GMP-Certified CDMO Specializing in Protein Production

Advanced Protein Production (APP) is a U.S.-based Contract Development and Manufacturing Organization (CDMO) specializing in GMP-certified protein production for research and clinical applications. With over a decade of experience in building and operating GMP-compliant facilities, APP’s leadership brings unmatched expertise in managing a United States GMP lab designed specifically for high-quality protein expression and purification.

By focusing on cutting-edge protein methodology, APP offers contract protein production to support pharmaceutical process development from discovery through preclinical and clinical trial stages. Our facilities are equipped to deliver consistent, scalable results tailored to the needs of modern biotech and pharmaceutical partners.

In addition, APP provides conjugation capabilities for the development of Antibody-Drug Conjugates (ADCs) and other protein conjugates. These are manufactured using our own GMP-grade materials by a highly experienced team with deep expertise in protein and conjugation chemistry.

For biotech companies developing next-generation protein-based therapeutics, working with a 100% U.S.-based CDMO ensures speed, quality, and regulatory alignment. APP delivers a streamlined path from concept to clinic — helping innovative therapies reach the market faster and more efficiently.

GMP-Certified U.S. Protein Production & CDMO Facility

At Advanced Protein Production (APP), we deliver GMP-certified protein production as a U.S.-based CDMO, supporting both academic research institutions and biotechnology/pharmaceutical companies. Our contract manufacturing services are designed to accelerate preclinical and clinical development with precision and compliance.

APP offers a comprehensive solution that includes:

  • Pharmaceutical process development

  • GMP-compliant scaled protein manufacturing

  • Purification and protein conjugation (including ADCs)

  • QC testing

  • Complete CMC (Chemistry, Manufacturing, and Controls) documentation

Operating from a state-of-the-art United States GMP lab, our expert team ensures every program is tailored to meet the unique regulatory requirements of each client. APP provides dependable, end-to-end contract protein production services that meet global quality standards.

U.S.-Based GMP Facility for

Protein Production and Conjugation

Advanced Protein Production operates a GMP-certified manufacturing facility in the United States, expertly designed to support contract protein production and conjugation workflows. Our flexible infrastructure includes dedicated space for fermentation, purification, protein conjugation, and QC testing, enabling a seamless, end-to-end process under strict regulatory compliance.

We leverage multiple expression systems — including yeasts (Pichia pastoris), Escherichia coli, and mammalian cells (CHO, HEK293) — to deliver clinical-grade protein molecules. These serve as therapeutic candidates or intermediates in both preclinical studies and clinical trials.

As part of our full-service CDMO capabilities, we also create and qualify Master Cell Banks (MCB) and Working Cell Banks (WCB) to support scalable, reproducible protein manufacturing.

  • NBS 150L BioFlo Fermentor

  • NBS 40L Fermentor

  • Wave Bioreactor Mixer Systems

  • AKTA Pilot GE FPLC purification system

  • AKTA Purifer

  • Hirayama Autoclave

  • Large capacity centrifuges

  • Bioprocess columns

  • Laminar flow hoods

Our Expertise in U.S.-Based GMP Protein Production & Conjugation

  • GMP Protein Expression & Production Using Multiple Host Systems

    Bacterial Expression (E. coli)

    Yeast Expression (Pichia pastoris)

    Mammalian Expression (CHO and HEK293)

  • Custom Protein Conjugation Services in a GMP Environment

    Chemical Conjugation – Cleavable Linker

    Chemical Conjugation – Non-Cleavable Linker

    Fusion Protein Conjugation

    Drug-to-Antibody Ratio (DAR) Evaluations

    Target Molecules – Peptides, Antibodies, Aptamers, and Others

Advance your protein today.